Background
CpGislandsarediscreteclustersofunmethylatedCpGdinucleotidesfoundinthehumangenomethatcontrolgeneexpressionbybindingtranscriptionfactors.CGBOisawidelyexpressedbindingproteinthatrequirestheCpGdinucleotidetobindDNA.CGBPbindsstrictlytounmethylatedCpGmotifsandactsasatranscriptionactivator.TheCXXCdomainofthisproteinisconservedinDNAmethyltransferase,humantrithorax,andmethyl-CpGbindingprotein(MBP),andisinvolvedinDNA-binding.CGBOhasotherdomainsinvolvedinprotein-proteininteractions,yetmorestudyisneededtodeterminethefunction. 

Concentration
0.2mg/ml

Description
RabbitpolyclonalantibodytoCGBP

Purification
ProteinApurified

Specificity
Mouse,rat,human

Isotype
IgG

Formulation
0.1%SodiumAzide,0.2%Gelatin,PBS

Storage
4°C,stablefor1yearfromthedateofshipment.Avoidrepeatedfreezingandthawing.Multiplefreeze/thawcyclesmayresultindecreasedperformance

AlternativeNames
2410002I16Rikantibody,5830420C16Rikantibody,AI426635antibody,CFP1antibody,CpGbindingproteinantibody,CXXC1antibody,CXXCfinger1antibody,CXXCfinger1PHDdomainantibody,CXXCfingerprotein1antibody,CXXCtypezincfingerprotein1antibody,CXXC1antibody,CXXC1_HUMANantibody,DNAbindingproteinwithPHDfingerandCXXCdomainantibody,hCGBPantibody,HsT2645antibody,PCCX1antibody,PHDfingerandCXXCdomaincontainingprotein1antibody,PHF18antibody,ProteincontainingCXXCdomain1antibody,SPP1antibody,ZCGPC1antibody,Zincfinger,CpGbindingtypecontaining1antibody

Application
WB:1:200-1:500;IF:1:100-1:500;ELISA;IP

Fig.1. WBanalysisofCGBPantibodywithK-562celllysates(A-1013).