Background
Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.

Description
ACVR1B Polyclonal Antibody, HRP Conjugated. HRP. Raised in: Rabbit.

Formulation
Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.

Specificity
Human

Isotype
IgG

Uniprot ID
P36896

Purification
>95%, Protein G purified

Immunogen
Recombinant human Activin receptor type-1B protein (150-300AA)

Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative Names
Activin receptor type-1B (EC:2.7.11.30), ACVR1B, ACVRLK4, ALK4, Activin receptor type IB, ACTR-IB, Activin receptor-like kinase 4, ALK-4, Serine/threonine-protein kinase receptor R2, SKR2

Application
ELISA

VCU0006

Epigentek我们的使命
通过创新和智能的研究，建立并成为表观遗传相关产品，技术和服务的全球领先，完整和系统的提供商。

我们的目标是：

• 协助研究人员解决表观遗传问题中的挑战。

• 开发表观遗传实验并将其简化并引入到表观遗传实验中。

• 通过出色的可靠性，速度，服务和质量来确保客户满意度。

• 鼓励并促进表观遗传学的研究，以用于潜在的医学应用。

• 通过对技术趋势的常规分析来开拓和创新表观遗传产品。

公司简介
作为表观遗传学公司，Epigentek Group Inc.是表观遗传相关研究的创新技术和产品的领先开发商和提供商。自2005年成立以来，该公司已经开发了一系列专有产品，可为表观遗传学相关的研究和药物发现提供完整，系统的解决方案。

Epigentek产品在全球享有盛誉的学术界，领先的制药公司和尖端生物技术公司广泛使用。这些独特的产品经过专门设计，可以使检测比当前使用的方法更简单，更快，更方便且更高效。Epigentek的产品通过遍布36个国家和地区的专业销售团队和全球分销商网络进行销售。确保我们技术的创新将使客户完全满意并在您的实验中获得最大的成功是我们的第一要务。

该公司特别强调其技术的速度和有效性，继续关注表观遗传创新，并广泛开发和增强其产品组合。